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Joana Guedes

Joana Guedes

PhD Student

PhD Student
Member type
CIBIO-InBIO, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas, 4485-661 Vairão, Portugal

Joana Guedes has a Bachelor’s Degree in Biology from the Faculty of Sciences of the University of Porto and a Master’s Degree in Oncology, with a specialization in Molecular Oncology, from the Institute of Biomedical Sciences Abel Salazar of the University of Porto. She developed her Master’s project at IPO-Francisco Gentil on the detection of mutations in potential predictive biomarkers of response to anti-EGFR monoclonal antibody treatment in metastatic colorectal cancer, and she also contributed to research at INEB on the role of stem cells in heart regeneration/repair in the post-infarction myocardium.

Before starting her PhD project, she integrated two research projects at CIBIO related to plant biology and evolution. The first, aimed at clarifying phylogenetic relationships and studying the population genetics of a plant species endemic to the Canary Islands. The second, explored the zinc deficiency response regulatory network in Arabidospsis thaliana and Oryza sativa (rice).

She is now a PhD student at CIBIO-InBIO, researching the still elusive monoterpenoid indole alkaloid pathway of the medicinal plant Catharanthus roseus. Her work’s aim is to characterize the specialized mesophyll cells (idioblasts) where two highly valuable alkaloids, vincristine and vinblastine, are thought to be synthesized and accumulated. In particular, to define the idioblast transcription profile and alkaloid content.


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